phosphorus regulation in body

High dietary phosphorus intake is associated with all-cause mortality: results from NHANES III. In adults aged 20 and older, the average daily phosphorus intake from foods is 1,189 mg for women and 1,596 mg for men. Am J Cardiol 2013;111:857-62. Replacing phosphorus-containing food additives with foods without additives reduces phosphatemia in end-stage renal disease patients: a randomized clinical trial. Vitamin D can also help to decrease inflammation of gums which is associated with periodontal (gum) disease*. This systemic condition is characterized by abnormal metabolism of phosphorus, calcium, PTH, and/or vitamin D; abnormal bone turnover, mineralization, volume, growth, or strength; and vascular or other soft-tissue calcification [46]. In fact, phosphorus is regularly noted as the second most profuse mineral in the human body, and is the second most important element when it comes to maintaining bone health and integrity, behind calcium . [, Chang AR, Miller ER, Anderson CA, et al. 2020 Jul 21;49(14):5008-5057. doi: 10.1039/c8cs01021h. This is a fact sheet intended for health professionals. [, Lopez FL, Agarwal SK, Grams ME, et al. The absorption rate for the phosphorus in phosphate additives is approximately 70% [24]. Phosphorus is a major part of almost all body cells and tissues, with 85% concentration in the teeth and bones. Phosphorylation and dephosphorylation of proteins regulate cell functions. Nephrol Dial Transplant 2012;27:990-6. The main function of phosphorus is in the formation of bones and teeth. Clin Perinatol 2018;45:129-41. Any mention in this publication of a specific product or service, or recommendation from an organization or professional society, does not represent an endorsement by ODS of that product, service, or expert advice. To maintain a healthy body, an average human must consume 700e1250 mg phosphorus every day. Association between dietary calcium and phosphorus intakes, dietary calcium/phosphorus ratio and bone mass in the Korean population. Boca Raton, Florida: CRC Press; 2018:249-66. Boca Raton, Florida: CRC Press; 2018:221-33. Jama 2011;305:1119-27. Because human intestines lack the phytase enzyme, much phosphorus in this form is unavailable for absorption [1]. It is thought that excess amounts of phosphorus intake for long periods are a strong factor in bone impairment and ageing. Itkonen ST, Karp HJ, Lamberg-Allardt CJ. Not all observational data, however, support a link between serum phosphate concentrations and CVD risk. Laxatives Trautvetter U, Jahreis G, Kiehntopf M, Glei M. Consequences of a high phosphorus intake on mineral metabolism and bone remodeling in dependence of calcium intake in healthy subjects - a randomized placebo-controlled human intervention study. EFSA Panel on Dietetic Products N, Allergies. According to one analysis, a very high calcium intake of 2,500 mg/day binds 0.61–1.05 g phosphorus [17]. [. Of all the phosphorus in the body, 80% of it is found in the teeth and bones in the form of crystalline bone, hydroxyapatite. Food Labeling: Revision of the Nutrition and Supplement Facts Labels. [, Lederer E. Regulation of serum phosphate. [, Murtaugh MA, Filipowicz R, Baird BC, Wei G, Greene T, Beddhu S. Dietary phosphorus intake and mortality in moderate chronic kidney disease: NHANES III. These additives are used for such purposes as preserving moisture or color and enhancing and stabilizing frozen foods [18]. According to an analysis of 2013–2014 NHANES data, the average daily phosphorus intake from both foods and supplements is 1,301 mg for women and 1,744 mg for men [32]. Kidney Int 2013;83:707-14. Michael T. Murray, ND Adv Sci (Weinh). J Nutr 1996;126:1168S-80S. Hospital Practice 2018;46:121-7. 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